What is 5 HTP?

5-Hydroxytryptophan or 5-HTP is a natural intermediate in the synthesis of the essential amino acid tryptophan. Free tryptophan crosses the blood-brain barrier and, upon reaching the brain, is converted into 5-HTP, which in turn is converted into serotonin.
Serotonin acts on the central nervous system, where it affects a wide range of conditions, including appetite, sleep or cognitive functions, and it is also well known for its ability to improve general mood.

What is the role of Pyridoxine Hydrochloride?

Pyridoxine Hydrochloride plays an important role in the functioning of the central nervous system. As a coenzyme, this vitamin is essential in the production of various neurotransmitters in the brain, including melatonin, norepinephrine and dopamine. In addition, it participates as an enzymatic cofactor in more than 140 biochemical reactions.
Because the Pyridoxine Hydrochloride metabolite pyridoxal 5-phosphate is a coenzyme in the tryptophan-serotonin pathway, Pyridoxine Hydrochloride deficiency theoretically causes depression. This theory is supported by studies that have reported low levels of vitamin B6 in depressed outpatients and for some authors this vitamin is considered an anti-stress agent.

Properties in combination - 5 HTP + Pyridoxine Hydrochloride

Supplementation with 5-HTP is more recommended than its precursor, L-tryptophan. 5-HTP is a natural derivative of the seeds of the Griffonia plant. L-tryptophan is produced synthetically or through bacterial fermentation. 5-HTP in the brain and in the presence of pyridoxal phosphate, which is the active form of Pyridoxine Hydrochloride and is included in this supplement, can synthesize serotonin.
This supplement based on 5-HTP has the advantage that, once the conversion of L-tryptophan into 5-HTP has taken place, the obstacles to serotonin synthesis are removed. Oral 5-HTP is very well absorbed from the intestine, without the need for a carrier, and is not affected by the presence of other amino acids. Therefore, it can be taken with meals without reducing its effectiveness.

Formation of serotonin from tryptophan: